Perform when setting the speakers manually or when changing settings made in Audyssey® Setup.
If you enable new speakers in the speaker configuration menu after performing Audyssey® Setup, you will no longer be able to select Audyssey MultEQ® XT, Audyssey Dynamic EQ® or Audyssey Dynamic Volume®. link
Changing the following settings:
Speaker size (Large or Small) / Distances / Levels / Crossovers settings will not disable Audyssey® or require running Audyssey® Setup again.
“Manual Setup” can be used without changing the settings. Please set if necessary.